Blender’s Notes Glymphatic Brain Cleanse ~ Micro-Nutrition:
Steep Me Micro-Nutrition combinations are a wonderful way to get health benefits of different combinations of Vitamins and Minerals. With this blend we are providing a healthy and potent blend of minerals and vitamins for managing the detox of your Glymphatic System. In addition, we included herbs to help your system ensure that your Adrenal Glands, Autonomic Nervous System, Liver, Pineal Gland, and Autophagy System function optimally to help your body rid what has been detoxed out of the glymphatic system. This Capsule will be done before bed since the Glymphatic System increased to 90% use while you are sleeping.
The glymphatic system is a recently discovered macroscopic waste clearance system that utilizes a unique system of perivascular channels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the central nervous system. Besides waste elimination, the glymphatic system may also function to help distribute non-waste compounds, such as glucose, lipids, amino acids, and neurotransmitters related to volume transmission, in the brain. Intriguingly, the glymphatic system functions during sleep and is disengaged during wakefulness. The biological need for sleep across all species may therefore reflect that the brain must enter a state of activity that enables elimination of potentially neurotoxic waste products, including β-amyloid. Since the concept of the glymphatic system is new, we will here review its basic structural elements, organization, regulation, and functions. We will also discuss recent studies indicating that glymphatic function is suppressed in various diseases and that failure of glymphatic function in turn might contribute to pathology in neurodegenerative disorders, traumatic brain injury and stroke. Clearance of excess fluid and interstitial solutes is critical for tissue homeostasis. In the peripheral tissues soluble material, proteins and fluid from the interstitial space are returned to the general circulation by the lymphatic system. The lymphatic network extends throughout all parts of the peripheral tissues and the density of lymph vessels correlates with the rate of tissue metabolism. Although the brain and spinal cord are characterized by a disproportionally high metabolic rate, and synaptic transmission is exquisitely sensitive to changes in their environment, the central nervous system (CNS) completely lacks conventional lymphatic vessels. This review addresses recent findings that shed light on this paradox and discusses these findings within the broader context of what is known about waste elimination from the CNS. Finally, we discuss our recent findings indicating that this system might also serve to distribute non-waste compounds such as lipids and glucose within the brain. The Glymphatic System – A Beginner’s Guide – PMC (nih.gov)
The glymphatic system, glymphatic clearance pathway or paravascular system is an organ system for metabolic waste removal in the central nervous system (CNS) of vertebrates. According to this model, cerebrospinal fluid (CSF), an ultrafiltrate plasma fluid secreted by choroid plexuses in the cerebral ventricles, flows into the paravascular space around cerebral arteries, contacts, and mixes with interstitial fluid (ISF) and solutes within the brain parenchyma, and exits via the cerebral venous paravascular spaces back into the subarachnoid space. The pathway consists of a para-arterial influx mechanism for CSF driven primarily by arterial pulsation, which “massages” the low-pressure CSF into the denser brain parenchyma, and the CSF flow is regulated during sleep by changes in parenchyma resistance due to expansion and contraction of the extracellular space. Clearance of soluble proteins, metabolites and excess extracellular fluid is accomplished through convective bulk flow of ISF, facilitated by astrocytic aquaporin 4 (AQP4) water channels. The name “glymphatic system” was coined by the Danish neuroscientist Maiken Nedergaard in recognition of its dependence upon glial cells and the similarity of its functions to those of the peripheral lymphatic system. Glymphatic flow was initially believed to be the complete answer to the long-standing question of how the sensitive neural tissue of the CNS functions in the perceived absence of a lymphatic drainage pathway for extracellular proteins, excess fluid, and metabolic waste products. However, two subsequent articles by Louveau et al. from the University of Virginia School of Medicine and Aspelund et al. from the University of Helsinki reported independently that the dural sinuses and meningeal arteries are lined with conventional lymphatic vessels, and that this long-elusive vasculature forms a connecting pathway to the glymphatic system. Glymphatic system – Wikipedia
THE GLYMPHATIC SYSTEM is a complex waste clearance pathway within the central nervous system that plays a crucial role in maintaining brain homeostasis, particularly because—unlike other tissues in the body—the brain lacks a traditional lymphatic system. Prior to the discovery of the glymphatic system in 2012, it was thought that only the blood-brain barrier tightly regulated the exchange of macromolecules between the bloodstream and the brain and that the primary mechanism for removal of protein waste was autophagy and ubiquitination of protein aggregates. The glymphatic system relies on the continuous interchange of cerebrospinal fluid (CSF) and interstitial fluid (ISF)—facilitated by aquaporin 4 (AQP4) water channels through the brain’s extracellular space to clear metabolic waste products and maintain a healthy environment for neuronal function. The glymphatic system operates via a process involving convective bulk flow, with CSF entering the brain’s extracellular space and mixing with ISF. This exchange is crucial for clearing metabolic waste found in the brain. The bulk flow is thought to be driven by arterial pulsation, which creates pressure gradients that propel the movement of CSF. The pulsation of arteries contributes to the directional flow of CSF from Virchow-Robin spaces (perivascular spaces surrounding small vessels) into the brain parenchyma, facilitating waste clearance. Sleep and wakefulness are also tied to glymphatic function. During sleep, the glymphatic system becomes 90% more active than during the wake state. As demonstrated in murine models, natural sleep or anesthesia is associated with a 60% increase in ISF volume, and this expansion promotes more efficient clearance of neurotoxic waste metabolites. On the other hand, sleep deficiency reduces perivascular flow and may lead to structural changes in perivascular spaces, which could explain the association between sleep disturbances and various neurological disorders such as Alzheimer disease (AD) and Parkinson disease.
The Glymphatic Pathway: Evaluating Neurological Conditions from a New Perspective
The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience – PMC
How to know I need a Glymphatic Brain Cleanse. A brain detox, or brain cleanse, is intended to help protect against neurodegenerative diseases and decrease symptoms related to poor brain function. Why do people try brain cleanses? Usually, to help manage symptoms such as Fatigue ~ Brain fog ~ Anxiety ~ Depression ~ Memory loss ~ Brain injury and stroke ~ Addictions. This type of cleanse usually involves steps such as prioritizing sleep, taking certain supplements that may help support brain function, eating an anti-inflammatory diet, exercising, and fasting if appropriate.
In this blend we started with our Steep Me Medicinal Mushroom Blend. Steep Me Medicinal Mushrooms are a potent antioxidant combination that can increase melatonin production and reverse hormonal imbalances. They also have anti-aging effects and protect against cellular damage, fostering neurogenesis and improving cognitive function. They are like a nourishing balm for your pineal gland, enhancing its function and helping you achieve a state of deep, intuitive awareness. Steep Me Medicinal Mushroom are exceptionally high in the polysaccharide beta-glucan, which has been found to reduce stress and healthy cortisol levels and improve immune system performance. They can also help boost energy production, enhance digestion and nutrient absorption, and restore hormonal balance plus since they are potent adaptogens and anti-inflammatories that activate autophagy. They have the highest ORAC measurement in the world for their antioxidant properties. They also improve red blood cell functioning. Steep Me Mushroom Blend was also added to protect the liver from damage by acetaminophen and other potentially toxic chemicals and reduce the damage that a high fat diet can do to the liver and may even lend some protection against diabetic effects on the liver. The mushrooms assist in controlling blood glucose levels, modulation of the immune system, offer liver protection, and help the body maintain optimal levels of bacteria. The mushrooms contain carbohydrates, fat, fiber, and protein along with some vitamins and minerals, potassium, calcium, phosphorus, magnesium, selenium, iron, zinc, and copper. The bioactive molecules found in the mushroom are terpenoids, steroids, phenols, nucleotides and their derivatives, glycoproteins, and polysaccharides. Polysaccharides, which make up about 8% of the mushroom, have several health benefits, including anti-inflammatory, hypoglycemic, antiulcer, anti-tumorigenic, and immune stimulating effects. Terpenes have also been shown to have anti-inflammatory, anti-tumorigenic, and lipid-lowering properties. Next, we included California Poppy and Valerian Root. California Poppy is known for its calming and sleep-inducing properties because it contains alkaloids like protopine and allocryptopine that act on GABA receptors in the brain, promoting relaxation and sleep. California Poppy is used as a nerve sedative that directly relaxes the nervous system, helps reduce pain, ease tension, and aids in going to sleep. It has a gentle, yet powerful pharmacodynamic action of soothing and nourishing the peripheral nerves and muscle tissue. It can help reduce anxiety, which is often a barrier to good sleep and its pain-relieving properties can also contribute to better sleep, especially for those with muscle pain or restless legs especially when combined with Valerian Root. Valerian root can help reduce the amount of time it takes to fall asleep, and it can enhance overall sleep quality, helping you spend more time in deep sleep stages. Valerian root has calming properties that can help reduce anxiety, which is often a barrier to good sleep. Valerian root helps calm the nervous system when it is overactive. It can do this by affecting levels of neurotransmitters involved in rest and sleep. It increases the amount of a certain neurotransmitter called GABA, which has calming properties which is likely why people find it helpful for battling anxiety and restless sleep. Deep, uninterrupted sleep is critical for overall health. Most people know that sleep is important, but they may not realize just how critical it is for overall health and well-being. Others suffer from bouts of insomnia and sleep anxiety. During sleep, the body has a chance to rest and repair itself. The brain also uses this time to cleanse itself of toxins that can build up during the day. If your nervous system is dysregulated, you might have sleep problems such as trouble falling asleep or waking up in the middle of the night. Gynostemma was added because it has anti-inflammatory properties that can help reduce inflammation in the body. It has been associated with youthfulness and longevity; it may help manage blood sugar levels and support metabolic health. It has adaptogenic properties, which can help the body manage stress more effectively and contains antioxidants like flavonoids and saponins, which help combat oxidative stress and promote healthy aging. White Willow has been added because it contains salicin, a chemical similar to aspirin, which helps reduce pain and inflammation, it has strong anti-inflammatory properties, making it useful for conditions like arthritis, bursitis, and tendinitis, it can help reduce fever, similar to how aspirin works, and it contains antioxidants like polyphenols and flavonoids, which help protect cells from oxidative stress. Cinnamon has been shown to support adrenal gland health by helping to regulate blood sugar levels. Maintaining stable blood sugar is crucial for adrenal function, as fluctuations can lead to increased cortisol production and stress on the adrenal glands. Cinnamon was added because it can improve insulin sensitivity and help keep blood sugar levels steady, which in turn supports adrenal health.
Ashwagandha was added because it may improve sleep quality, which is essential for the glymphatic system to function effectively. By reducing stress and anxiety, Ashwagandha can promote relaxation and better sleep, allowing the glymphatic system to clear waste products more efficiently and its anti-inflammatory properties may support overall brain health and improve the functioning of the glymphatic system and helps balance cortisol levels and reduce stress. Ashwagandha helps prevent the depletion of cortisol and vitamin C (which is highly concentrated in the adrenal glands) in the adrenals following a stressful event. Hibiscus was added because it can help improve liver function and detoxification processes. Plus, it has antimicrobial properties that can help protect against infections and can help improve digestion and relieve symptoms such as bloating and indigestion. The anti-inflammatory properties of hibiscus can help reduce inflammation in the body. and is rich in vitamin C, hibiscus can help boost the immune system and fight off colds and flu. Horseradish contains essential nutrients like vitamin C, calcium, magnesium, potassium, and folate. It is rich in antioxidants that help combat oxidative stress and protect cells from damage. Compounds in horseradish, such as sinigrin, have anti-inflammatory properties that can help reduce inflammation in the body. Horseradish has antimicrobial properties that can help fight infections. It can aid digestion and relieve symptoms like bloating and indigestion. The high vitamin C content in horseradish supports the immune system. Horseradish can help support the body’s natural detoxification processes. Steep Me Ginseng Blend can serve as an adaptogen. Kings and emperors of the past have placed great emphasis on ginseng to fortify their health. It accomplishes these goals by fine tuning the adrenal gland and reestablishing a proper cortisol level. Cortisol is a hormone secreted by the adrenal gland. boosts the immune system, improves cognitive function, enhances physical stamina, and reduces stress and anxiety. It also has potential anticancer properties and may help in preventing specific types of cancer. Garlic was included because it can enhance immune function, garlic has anti-inflammatory properties that can help reduce inflammation in the body, it contains antioxidants that help combat oxidative stress and protect cells from damage and it may improve physical performance and reduce fatigue. Next, we added Dandelion. Dandelion was included because they contain potent antioxidants like beta-carotene and polyphenols, which help neutralize free radicals and protect against cell damage which is important during a cleanse. Compounds in dandelion may help reduce inflammation, which is beneficial for overall health, support liver function and detoxification, improve digestion and relieve symptoms like bloating and constipation, help lower cholesterol levels, reducing the risk of heart disease, acts as a natural diuretic, helping to flush out excess fluids and reduce bloating. Plus, the antioxidants and nutrients in dandelion can help boost the immune system. Dandelion can be used as a liver tonic, a medicinal substance that can boost vitality. It has antioxidant properties that help protect the liver against oxidative stress. Dandelion root is also a type of digestive bitter, a substance that stimulates bile production and enhances bile flow from the liver. Adequate bile production is important for proper digestion of fats and the elimination of toxins and waste products from the liver. Bitters work their digestive magic by stimulating the release of the digestive hormone cholecystokinin (CCK) which stimulates bile flow from the liver and gallbladder as well as digestive enzyme release pancreas.
We also added Gingko. Gingko was also added because it can help improve blood flow by dilating blood vessels and reducing blood viscosity, which can benefit cardiovascular health, contains flavonoids and terpenoids, which are powerful antioxidants that help combat oxidative stress and protect cells from damage. It has anti-inflammatory properties that can help reduce inflammation in the body and has a positive effect on mood and help reduce symptoms of anxiety and depression. Gingko Biloba has great cognitive benefits, it enhances blood flow to the brain, ensuring your pineal gland gets the oxygen and nutrients it needs. This increased circulation helps you stay focused and clear-headed during your manifestation practices. Gingko because it is known for its adaptogenic properties, which can help support adrenal health by reducing stress levels. It has been shown to lower cortisol levels, which is beneficial for adrenal function. Additionally, ginkgo biloba is rich in antioxidants, which help reduce the effects of free radicals and lower inflammation. Gingko Biloba is a nervine stimulant by activating nerve endings by increasing circulation and increasing vitality and zest. It can be helpful in improving things like anxiety, memory, cognitive function, and more. Ginkgo works by altering levels of neurotransmitters like serotonin and GABA, and by lowering inflammation in the nervous system. This makes it helpful for boosting nervous system function and preventing deterioration and damage. Bacopa because it helps balance the level of the potentially damaging stress hormone cortisol and helps support healthy adrenal function. Adaptogens are herbal remedies that make you more resilient to stress of all kinds — mental, physical, and environmental. Bacopa was added because it increases cerebral circulation, which can help create more cerebrospinal fluid (CSF) to wash the brain of toxins. Bacopa contains powerful antioxidants called bacosides, which can help neutralize free radicals and prevent oxidative stress. Bacopa has been shown to reduce inflammation, which is beneficial for overall brain health. By reducing stress and anxiety, Bacopa can promote relaxation and better sleep, allowing the glymphatic system to clear waste products more efficiently. Next, we included Black Ant. Black ants are high in minerals such as potassium, calcium, phosphorus, magnesium, iron, manganese, and zinc. The nutrients in black ants can help increase energy levels and stamina. The zinc and other nutrients in black ants can boost the immune system and help fight off infections. Black ants can support liver detoxification, promote overall liver health, help combat oxidative stress and support longevity. Black ants can aid in the digestion of fats and improve protein assimilation which is crucial for removal of toxins. Lodhra because it has strong anti-inflammatory properties, which can help reduce inflammation in the body, contains antioxidants that help protect cells from oxidative damage, helps balance hormone levels, supports liver function and can help with conditions like jaundice and liver inflammation, aids digestion and can help with issues like indigestion, constipation, and diarrhea. Uva Ursi is traditionally used to treat UTIs and bladder infections due to its natural antibacterial and astringent properties, it helps reduce inflammation, which can be beneficial for conditions like cystitis, it contains antioxidants that help protect cells from oxidative damage, it acts as a diuretic, helping to flush out excess fluids and toxins from the body. Next, we added Chanca Piedra. Chanca Piedra was included to ensure your body carefully removes all the toxins from the cleanse. It is best known for its ability to help dissolve kidney stones and prevent their formation, and it supports liver function and may help protect against liver damage. Chanca Piedra can help with digestive issues, including stomach ulcers caused by Helicobacter pylori and has anti-inflammatory properties that can help reduce inflammation in the body. The antioxidants in Chanca Piedra can help combat oxidative stress and support overall health and can increase urine flow and help flush out toxins from the urinary tract.
Turmeric and Cayenne Pepper. Turmeric contains curcumin helps reduce inflammation, which can improve overall brain health and support the glymphatic system’s function. Turmeric’s antioxidants help neutralize free radicals, reducing oxidative stress and promoting a healthier brain environment. By aiding the body’s natural detoxification processes, turmeric can help remove waste and toxins from the brain, enhancing the glymphatic system’s efficiency. Cayenne Pepper was added to help improve how turmeric works plus has a multitude of its own health benefits. The capsaicin can help reduce pain by blocking substance P, a chemical messenger that transmits pain signal. o the brain. It can boost metabolism and reduce hunger, aiding in weight loss, has anti-inflammatory properties, which can help reduce inflammation in the body, improve digestion and relieve symptoms like gas, bloating, and cramps, it can help boost the immune system, it can improve blood circulation and reduce the risk of heart disease, and it can help clear congestion and ease symptoms of colds. L. Arginine because it helps produce nitric oxide, a molecule that relaxes blood vessels and improves blood flow, which can benefit heart health. L-arginine supplements can help lower both systolic and diastolic blood pressure, it supports the immune system by aiding in the production of T-cells, which are crucial for immune response, helps improve kidney function, and it supports the metabolism of protein by maintaining nitrogen balance in the body. Glycine was included because it can help your body produce glutathione, a powerful antioxidant that protects your cells from oxidative damage. Glycine can help improve sleep quality, making it easier to fall asleep and stay asleep. It is a component of creatine, which provides energy to your muscles and supports muscle growth and performance. Glycine can help improve insulin sensitivity and support blood sugar regulation and it may help reduce the risk of heart disease by lowering blood pressure and improving cholesterol levels. Glycine can help protect the liver from damage, especially from alcohol consumption. and supports brain health and may improve memory and cognitive function. Korean Pine Needle has antioxidant, antiseptic, antibacterial, and antifungal properties. Korean red pine needle oil benefits the ability to cross the blood-brain barrier, clean up arterial plaque and dissolve gallstones combined with its antimicrobial, antifungal, antibacterial, antiviral and antiparasitic properties put it among the best of the best which helps the body’s vital organs get rid of waste and fatty lipids. The combination of Vitamin A, carotene, and Rustin gives Red Pine a tripe boost of antioxidants. Antioxidants are known to neutralize free radicals. Less free radicals in the body mean slower cell deterioration, and this helps to slow the aging process and keep the skin and hair looking healthy. Antioxidants are also known to protect the body from nervous system disorders and muscle degeneration. It also contains carotene. The body converts carotene into Vitamin A, providing yet more antioxidant potential. Resveratrol was added because it neutralizes free radicals, protecting cells from damage. Resveratrol has neuroprotective effects, which may help preserve memory and cognitive function. It reduces inflammation, which can benefit conditions like arthritis and other inflammatory diseases and promote longevity by activating certain genes associated with aging. Finally, we added Kava Kava. Kava Kava is well-known for its ability to reduce anxiety and promote relaxation. It can help improve sleep quality and reduce insomnia. Kava kava has been used to relieve pain, including muscle pain and headaches. It has anti-inflammatory properties that can help reduce inflammation in the body and may enhance cognitive function and memory. Plus, Kava kava contains antioxidants that help protect cells from damage.
With our entire line of Brain Support ~ Mental Sharpness ~ Stroke Recovery ~ Alzheimer’s & Parkinson’s Phyto~Nutrition Tea and Micro~Nutrition Tea Options we have a great solution for you. We approach this diagnosis with Phyto~Nutrition and Micro~Nutrition to manage the symptoms. These items can work in conjunction with each other. Please ask any questions you may have!
NOTE: “This/these claim(s) has/have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.”
Features Glymphatic Brain Cleanse ~ Micro-Nutrition:
- Ready to Go
- Lots of individual flavor based on the ingredients.
- All Wildcrafted Herbs
- All Organic where Wildcrafted is not available.
- 1 Capsules a Day Until Gone…taken before bed!
- Caffeine: None
Ingredients: Steep Me Proprietary Organic and Wild crafted Blend of Steep Me Medicinal Mushrooms, California Poppy, Valerian Root, Gynostemma, White Willow Bark, Cinnamon, Ashwagandha, Hibiscus, Horseradish, Dandelion, Gingko, Bacopa, Black Ant, Lodhra, Uva Ursi, Chanca Piedra, Turmeric, Cayenne Pepper, L. Arginine, Glycine, Korean Pine Needle, Resveratrol and Kava Kava ~ No Fillers ~ No Gluten ~ No Dairy
Alternatively, try our Brain Health Phyto~Nutrition Tea OR Alzheimer’s Phyto~Nutrition Tea OR Alzheimer’s Phyto~Nutrition Capsules OR Mental Sharpness Phyto~Nutrition Tea OR Mental Sharpness Phyto~Nutrition Capsules OR Mental Health ~ Bipolar Phyto~Nutrition Capsules
** Not Safe for Pregnancy ~ Not Safe for Breastfeeding
NOTE: This/these claim(s) have/have not been evaluated by the Food and Drug Administration. The products offered by Steep Me Tea Apothecary -Franchisees – Wholesalers – Influencers or SteepMe.com are not intended to treat, cure, or prevent any illness or disease. If you have or suspect that you have a medical problem, consult with your physician for diagnosis or treatment. All gender specific blends are based on Gender Assigned at Birth. Use herbs as per instructions and always watch for any allergic reactions. You should always carefully read all product packaging and labels. Always consult your physician or health care provider before using any herbal products, especially if you have a medical problem. Steep Me Tea Apothecary and SteepMe.com and/or its proprietors assume no liability for any injury, illness or adverse effects caused by the misuse and/or use of the information or products presented
NOTE: When using Teas, Capsules, Tinctures and Micro-Nutrition to help with your ailment ~ please remember this is a marathon ~ we recommend an investment of time of at least 6 months to see positive change. Any gender specific blends are based on gender assigned at birth.
Benefits of taking a supplement through capsule form. https://www.realpromise.com/en/what-are-the-advantages-of-capsules/
